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Interchim Puriflash® Purification and Preparation System

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Customized services to ensure the success of your purification and identification.


Simple and quick: Powerful yet easy to use, InterSoft®X software is simple and intuitive, enhancing chemists’ workflows.
Superior chromatographic column performance and a comprehensive product range: Analytical/Flash/Prep/DAC column;
Simplified workflow: Make mass spectrometry-based identification and purification preparation easier and faster;
Multiple detection methods: UV, ELSD, and MS—covering low, medium, and high pressures;
Safe operation: Leak detection, RFID, and overpressure management features to prevent product loss;
Rich application scenarios: Identification of organic small molecules, natural products, impurities, peptides, oligonucleotides, metabolites, and enrichment of trace substances, etc.

 

| Flash Purification Systems for Rapid Purification


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Flow rate

(ml/min)

Maximum pressure

(bar)

PuriFlash ® XS 520 Plus

Small but mighty

300

20

X

PuriFlash ® 5.020

Daily purification partner

300

20

PuriFlash ® 5.050

Simultaneously compatible Flash and Prep

250

50

| Process Purification Systems


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Flow rate

(ml/min)

Maximum pressure

(bar)

PuriFlash ® 535-XL

Guarantee of production capacity

400

35

PuriFlash ® 5.015‐XL

Process-Kilo-Lab Kilogram-scale preparation

825

15

| High-Pressure Preparative Purification Systems


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Flow rate

(ml/min)

Maximum pressure

(bar)

PuriFlash ® 5.250

A powerful assistant for separating complex systems

250

250

PuriFlash ® 5.400-UV

Ultimate bacterial separation and isolation tool

125

400

| Peptide & Oligonucleotide Purification Systems


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Flow rate

(ml/min)

Maximum pressure

(bar)

PuriFlash ® 5.250P

Separate complex multi-brain mixtures

 

125

250

         

| Flash Smart Purification Technology


What is intelligent purification?
By leveraging rapid, preparation-free analytical techniques and AI assistance, the processes of synthesis, purification, and identification are broken down into simple steps, making purification and identification more straightforward.


How to perform intelligent purification?
Intersoft®X software and Genius can recommend the optimal purification method for you, enabling rapid method development and making the process more convenient and efficient.
Step 1: Monitor the reaction using TLC thin-layer chromatography.
After the reaction, samples were taken by TLC. Using a combined TLC/CMS approach, spots were directly sampled from the thin-layer chromatography plate and then identified using the expression®CMS compact benchtop mass spectrometer.
Step 2: Conversion from TLC to Flash method
Using the mobile app, the TLC-to-Flash method conversion is achieved, enabling the upload of thin-layer chromatography separation data into the Flash system. This provides optimal separation conditions for fraction collection, followed by purification using the puriFlash® system.
Take a photograph of the thin-layer chromatography plate, enter the file name, mark the spots of interest, the purification yield, and the solvents used. The data is then sent via Bluetooth to the puriFlash® system, where the Genius software automatically assists in building the method.
The screen displays the total UV spectrum, where you can locate the peaks in the graph for use in the next step of fraction confirmation analysis.
Step 3: Obtain the fraction ID in under 30 seconds.
To collect fractions via UV, it is necessary to confirm the fraction IDs to ensure that the target compounds have been eluted. You can take a small sample of each compound’s fraction and analyze it using ASAP/CMS.
Fraction confirmation via ASAP and expression®CMS requires simply dipping the probe into the fraction collection tube to collect a sample, then directly inserting it into the mass spectrometer—results can be obtained within 30 seconds.


Summary
Combining Flash intelligent purification, expression®CMS, the TLC thin-layer chromatography-mass spectrometry interface, and the ASAP direct-injection analysis probe, you can streamline your workflow with simple sampling techniques, intuitive software, and advanced detection technologies, enabling you to synthesize, identify, and purify your compounds easily and with confidence.
Through an intuitive workflow, the following can be ensured:
√ Use TLC and expression®CMS to identify and purify the desired thin-layer chromatography spots;
√ Establish an optimized method using the puriFlash® purification system and Genius software;
√ Use ASAP direct injection analysis with the probe and the expression®CMS compact benchtop mass spectrometer for fraction confirmation.

>Learn more

Introduction to AIS Purification and Preparation Systems and Organic Mass Spectrometry Products

5.2MB

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