Peptide Synthesizer PurePep® Sonata®+

Product Details Ordering Information Download Materials Related video Application Cases

PurePep ^®Sonata ^®+

Reliably scale up production and boost productivity.

New generation PurePep ^®Sonata ^®+ The instrument is our single-channel pilot-scale peptide synthesizer. Sonata ^®XT Built on this foundation, it carries forward its quality and outstanding features. PurePep Sonata+ Demonstrates batch-to-batch reliability at the pre-production scale and productivity level, meeting... CRO/CMO And pharmaceutical companies need it. 21 CFR Part 11 Compliant, intuitive software and hardware upgrades enable... PurePep Sonata+ Easy to operate. Inheriting proprietary... PurePep ^®Pathway Valve block system, in conjunction with Single-Shot Liquid delivery technology eliminates the risk of reagent cross-contamination, ensuring unparalleled peptide purity. Variable mixing modes enhance productivity.

Real-time traffic monitoring technology

Precise liquid delivery with low calibration requirements.

Real-time traffic monitoring technology is PurePep Sonata+ Its proprietary technology ensures accurate and precise liquid delivery by continuously monitoring flow velocity. Based on sonar principles, this technology measures flow velocity by transmitting sonar signals in both directions. For liquids with different viscosities, only a single calibration is required, minimizing user calibration efforts and saving time. This technology maintains high precision even when flow velocity changes, with measurement errors consistently low across a wide variety of liquids. <5%。

Intuitive software

The graphical software platform simplifies the setup of peptide synthesis methods and accelerates the development of new peptide synthesis protocols. Predefined standard experimental protocols can serve as templates for custom configurations, maximizing efficiency and flexibility; additionally, sequences can be easily imported to minimize errors. The platform enables programming new synthesis tasks concurrently with ongoing synthesis runs, thereby enhancing production efficiency. This software complies with... 21 CFR Part 11 Requirements: Ensure that the instrument is suitable for highly regulated environments. cGMP Laboratory environment.

Single-Shot Pre-Activation

Using a specially designed three-port flow path module, alternating flow paths can be achieved, thereby optimizing the solvent delivered to the amino acid vials and enabling... Single-Shot Pre-activation. Thanks to the efficient blocking valve and cleaning of the delivery pipelines, product purity has been enhanced.

PurePep Pathway Technology

Proprietary chemically inert valve block system PurePep Pathway and Single-Shot The pre-activation function jointly eliminates the risk of reagent cross-contamination and enhances the purity of crude short and long peptides.

Multiple hybrid mode

PurePep Sonata+ Chemically inert and optimized flow channels enable high solution transport rates for any solvent. >400 mL/min ). All reactions are carried out in an inert environment to minimize side reactions. A variety of mixing modes—including nitrogen bubbling, variable-speed oscillation, and recirculation—are available, and can be used individually or in combination to maximize reaction efficiency.

Enhanced pump and other hardware

A fast and flexible main solvent pump with chemical resistance and extremely low maintenance requirements. A Teflon-lined circulation pump offering high solvent compatibility and easy maintenance. It can be easily connected to external solvent and waste liquid systems. GL45 The amino acid bottle configuration offers great flexibility. Adopted by Single-Shot Pre-activation technology enables higher purity and eliminates the risk of reagent cross-contamination.

Solvent and Reagent Positions

Seven solvent ports and twenty reagent ports allow for easy customization of any synthesis protocol. Real-time flow technology ensures precise delivery of all solvents and reagents. To minimize disposal costs, two waste liquid ports enable separation of waste streams. Additionally, one collection port can be configured to collect cleavage products or recover valuable reagents, thereby maximizing versatility.

Installation and Operational Qualification (IQ/OQ)

Installation Qualification ( IQ ) and Operational Qualification ( OQ Support services, ensured by certified engineers, guarantee that the instruments strictly comply with all requirements—from delivery and installation through to operation. GPT Standardize and generate complete documentation for you in cGMP Provides solid support for operations under the regulatory environment.

Number of reaction vessels	1
Synthesis scale range	1mmol Up to 200 mmol
Reaction vessel volume	200mL 500mL, 1.2L, 2L, 3.2L, 4.2L
Number/Specification of Solvent Positions	1 Single main solvent tank, capacity from 1L to 200L (Users may use their own containers or opt for containers with specific specifications.) 6 User-defined solvent levels, with individual capacities ranging from 0.5 L to 8 L.
Number of amino acid sites	20 Each, with specifications of 500mL or 1L
Supported chemical methods	Fmoc t-Boc, organic, peptidomimetics, combinatorial chemistry, and others
Activation method/reagent	HBTU HATU, HCTU, TBTU, PyBOP, DIC/OxymaPure®, DIC/HOBt
Fluid Measurement Technology	Fluid Transport Based on Real-Time Flow Technology
Fluid delivery method	Delivery of main solvents and reagents: Using a positive-pressure nitrogen system. Delivery of the main solvent: Equipped with a dedicated pump
Mixed method	Nitrogen bubbling (adjustable), variable vortex, circulating mixing Can be used individually or in combination.
Cutting	Automatically performed, with programmable control (applicable only to Fmoc chemistry).
Waste liquid container	Standard configuration: 2 x 20L containers, with overflow sensor. Optional: Can be upgraded to a 200L capacity.
Control interface	Dedicated PurePep control software, including a standalone computer and a flat-panel display.
Report	Real-time logging of each instrument’s functional operations, with the ability to print logs to files or printers. Includes an email notification feature: emails can be sent to your computer or mobile phone at the start of specific program steps, at the beginning of each cycle, or when an error occurs.
Power supply	115 V/60 Hz or 230 V/50 Hz
Dimensions (width x depth x height) cm	89x58x161 (35” x 23” x 63.5”)
Weight	182 kg (400 lbs)
Warranty	One year, including parts and labor.