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Clarity
Clarity Oligo-RP is specially designed for the reversed-phase purification of oligonucleotides, balancing both hydrophobic and polar selectivity. The filler uses organic hybrid TWIN™ technology, which improves the selectivity and column efficiency for analyzing oligonucleotides.
Clarity Oligo-RP™ used for the purification and characterization of oligos
- Can separate N-1 failure sequences in target oligonucleotides, with purity reaching over 90%;
- Supports purification of DNA, RNA, thiol-modified, and various labeled oligonucleotides after detritylation;
- Can meet sample loading needs of 5 μmol or more based on preparation specifications and particle size;
- Can purify oligonucleotides up to 60 mers in length;
- Can be used as a reverse-phase HPLC column for oligonucleotide quality control (QC).
Prepare and purify on Oligo-RP
Reverse-phase separation of oligonucleotides has more advantages compared to other separation methods like ion exchange. The Oligo-RP stationary phase allows for high sample loading, excellent recovery and purity, and avoids extra purification steps. This is thanks to the ion-pair separation method that separates de-tritylated oligos from failed sequences and other impurities.
Separate N-1 failed sequences from the target N sequence
The Oligo-RP filler is specially designed to match the various properties of nucleotides and has a reactivity pattern that fits itself. The filler surface contains hydrophobic, dipole, π-π, and hydrogen bond donor/acceptor sites. This combination of interactions, along with ion-pair reagents, allows for highly selective differentiation between nucleic acids. As a result, this filler can detect extremely subtle differences in nucleotide sequences, like a single base difference (N and N-1) or a single base substitution.
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Address: Building 2, 8th Floor, No. 248 Guanghua Road, Minhang District, Shanghai市
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Copyright © 2026 Shanghai HanKing Instrument & Equipment Co.,Ltd
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