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Interchim puriFlash Process Scale-up

Product Details Ordering Information Download Materials Related video Application Cases

 

PuriFlash ® 535-XL

Guarantee of production capacity

 Conventional Flash Purification puriFlash XS 520 Plus Interface Flow rate: 400ml/min   Conventional Flash Purification puriFlash XS 520 Plus Interface Maximum pressure: 35bar

Reliability, with remarkable loading capacity.

Reliable and safe— 535XL Capable of semi-continuous production, effectively purifying compounds up to hundreds of grams. This system is compatible with various sizes. DAC Chromatographic columns (axially compressed columns) and preparative liquid chromatography columns—meeting all your purification needs.

Organic small molecule

●●●●●

Impurity Identification

●●●●○

Natural product

●●●●○

Polypeptide, oligonucleotide

●●●○○

Proteins, biological drugs

●●○○○

Separation of metabolites

●●○○○

Trace analysis

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Intersoft ® X Genius Smart software

User-friendly interface, easy to operate, and intelligent method development.

Control module

15 Inch touchscreen

Remote control

USB x4 RJ45

Fraction collector

2 a reagent rack

112 pipe 18 x 150 mm

Leakage and Waste Disposal System

Chromatographic column

Inner diameter can reach 80 mm

Injection system

Supports solid and liquid sample injection

UV 200-400nm

UV 200-800nm

(Pack-UV extended)

Multi-wavelength and full-spectrum scanning for spectral visualization and purity confirmation.

Flow cell: 0.3 mm / 40 µL

 

 

 

 

 

PuriFlash ® 5.015‐XL

Kilogram-scale preparation

 Conventional Flash Purification puriFlash XS 520 Plus Interface Flow rate: 825ml/min   Conventional Flash Purification puriFlash XS 520 Plus Interface Maximum pressure: 15bar

 

Reliability and stability, with significant load-bearing capacity.

Reliability, stability, and safety are key advantages of semi-continuous preparation, using... puriFlash 5.015-XL No matter what the magnification factor is, you can achieve production continuity on the same device.

Organic small molecule

●●●●●

Impurity Identification

●●●●○

Natural product

●●●●○

Polypeptide, oligonucleotide

●●●○○

Proteins, biological drugs

●●○○○

Separation of metabolites

●●○○○

Trace analysis

●●●●●

 

 

 

Intersoft ® X Genius Smart software

User-friendly interface, easy to operate, and intelligent method development.

Control module

15 Inch touchscreen

Remote control

USB x 8 RJ45

Fraction collector

3 a reagent rack

42 pipe 29.5 x 200 mm

Leakage and Waste Disposal System

Chromatographic column

Inner diameter can reach 150 mm

Injection system

Supports liquid sample injection and dry sample loading.

Column balance

Load & Go Technology

Six-way valve +10 Valve-controlled solid-phase loading

UV 200-400nm

UV 200-800nm

(Pack- UV extended)

Multi-wavelength and full-spectrum scanning for spectral visualization and purity confirmation.

Flow cell: 0.3 mm / 80 µL

 

| Ultraviolet - Visible Spectrophotometer Detector

 

Choose the UV that suits your needs. - Visible Spectrophotometer Detector

 

PuriFlash Ultraviolet included with the device - The visible spectrophotometer detector is fully integrated into the acquisition module, and is composed of... InterSoft X Software control. Since the application is very simple, you only need to enter the desired wavelength into the software and can simultaneously select... 4 a single wavelength, in a manner identical to scanning (the total number of wavelengths available for both models can be included in this model), “Genius” Will be responsible for the acquisition and recording of chromatograms.

 

Each laboratory has different needs. Since we are eager to meet these needs and always provide you with the right solution, we recommend using two types of UV detectors:

 

200 – 400 nm (Standard For proteins PF-020B Except)

 

200 – 800 nm (Compatible with this option) PuriFlash ® of the UV Expansion pack)

 

 

Real-time scanning across the entire wavelength and ultraviolet spectrum

 

Ultraviolet - The visible spectrophotometer detector is equipped with... “DAD” Technology (diode-array detector). This provides approximately one hundred diodes for scanning the entire wavelength range for detection, enabling real-time acquisition of the UV spectra of eluting compounds.

 

If you wish, you can at any time—even during operation or reprocessing—return to the peaks in the chromatogram to display the spectrum at the selected time and obtain identification of the elements as well as the purity of the purified compound.

Configuration

PuriFlash ® 535-XL

PuriFlash ® 5.015-XL

Pump

Flow rate (ml/min)

400

825

Maximum pressure (bar)

35

15

Quadruple Gradient Pump

Air venting

X

Washing discs

X

Pump Washing Discs (Pack)

X

X

Detector

UV: 200 – 400 nm

UV: 200 – 800 nm

Pack-UVextended

Pack-UVextended

Purity Confirmation

iELSD (pack)

X

X

Load sample

4 Electrically operated valve

X

X

6 Electrically operated valve w/loop

X

X

6 Pass-through valve +10 Electrically operated valve w/loop

X

X

Liquid, Dry-Load Load sample

Chromatographic Column Selection Valve

6 Electrically operated valve

X

X

System Configuration

Tubings – after pump (ID)

1/8” x 1.6mm

1/8” x 2.4mm

Flow cell

0.3mm/40 mu L

0.3mm/80 mu L

Chromatography column holder

Integration

Pack-ColHolder

Pack-process

Pre-column Column support

Pack-process

Fraction collection

Regular

2 A reagent rack

112 pipe 18x150mm

3 A reagent rack

42 pipe 29.5 x 200 mm

Control module

15 Inch touchscreen

USB

4

8

RJ45

Software

Intersoft X

Safety

Leak detection (pump, collection rack, iELSD , bracket)

X

√ (except for the bracket)

Solvent tray with drainage system

Collector with drainage system

Solvent level monitoring

RFID

X

Fume Enclosure

Size

E:D:H (cm)

35.5 × 47 × 77

40×51×75

Introduction to AIS Purification and Preparation Systems and Organic Mass Spectrometry Products

5.2MB

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