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2026
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【New Benchmark for Peptide R&D Efficiency】High-throughput synthesis and ultra-fast detection dual system working together, efficiently tackling R&D challenges
Stuck in peptide R&D? Low synthesis purity, hard optimization, slow analysis, low throughput, long cycles, and high costs are all common industry headaches! Is your peptide synthesis also trapped in the dead loop of 'low purity, long cycles, high cost'? Don’t scroll away! This article might just be the breakthrough you’ve been waiting for.
Integrated analysis of dual-device linkage scheme: PurePep® Chorus (top left) enables high-purity, automated, multi-batch peptide synthesis with online sampling; expression CMS (top right) is an organic mass spectrometry system for high-throughput, fast-feedback, and precise detection, providing real-time guidance for process optimization. By linking the two, you get an efficient workflow of 'synthesis → detection → optimization → re-synthesis,' which helps shorten R&D cycles, reduce trial-and-error costs, and is suitable for universities, research institutes, CROs/CDMOs, pharmaceutical companies, and any peptide research entity!
👉Painpoint
❌ Long peptides / complex peptides have low synthesis purity, high failure rates, and expensive purification later on.
❌ Optimizing under multiple conditions is tedious, and doing it manually is costly and error-prone
❌ Traditional mass spectrometry is slow and not efficient for large-scale screening.
❌ Monitoring is slow, and trial-and-error for process optimization is costly
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PurePep® Chorus：Peptide Synthesis 'Efficiency Pro'
Key Highlights
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6-channel parallel synthesis, antigen peptide crude peptide purity 85%-98%，Synchronous long sequences, unattended。
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Synthesis of a long peptide with 58 amino acids，No pre-activation → with pre-activation, purity jumps from 20% to 35%, a direct 15% increase in purity，Greatly cuts down on later purification time and reagent costs!
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You can freely adjust the reaction amount, temperature, and time，The purity of PNA synthesis can reach up to 87%
PNA Condition Optimization Test Data👇
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Seamless process scaling，The MT-II peptide's purity is almost the same between small-scale tests and mass production, with zero process deviation.
Advantages
✅ Fully automated: synthesis-cutting-purification all in one, sample addition cycle under 20 seconds, 10 µmol peptide condensation at 90°C in under 8 minutes
✅ Save ingredients: Single-Shot technology, all precious/non-natural amino acids added without rinsing, completely avoiding waste
✅ PurePepPathway flow design: each channel allows independent and fast sample loading, reducing cross-contamination, with precise dosing by the quantitative device;
✅ Precise temperature control: reaches 25-90°C quickly (10-20 seconds), 6 channels can be set to different temperatures, suitable for different sequence needs
✅ Compliance Design: Meets 21CFR PART11 and cGMP, directly compatible with pharma/CDMO R&D
✅ Real-time monitoring: UV samples every 10 seconds to make sure the protection is fully removed and reduce impurities from the source.
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expression CMS Organic Mass Spectrometry System: 30 seconds per sample! Lightning-fast mass spectrometry analysis, unlocking a new level of research efficiency
Auto Sampler OPSI Ion Source CMS Compact Mass Spectrometer，The three work together to create a lightning-fast testing system, fully automated from sample entry to results!
Key Highlights
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30-second single-needle analysis, flux increased 5-10 times，Speed up the research progress and lower the cost of analyzing each sample.
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Automatic sampler（Precise timed sample injection）、OPSI Ion Source（Convert peptide molecules into gas-phase ions, suitable for high flow rates）、CMS Mass Spectrometer（Quickly catch the signal）。Pair with short columns or use direct injection mode to shorten analyte residence time and lay the foundation for super-fast performance。
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Inject sample in 10-15 seconds（Quickly push the sample with the mobile phase）、High-speed rinse and fast scan collection（Use selected ion monitoring when the target is clear to improve the signal-to-noise ratio.）、System reset. It automatically cleans the needle while collecting, preventing cross-contamination, and all steps connect seamlessly.
Above picture: The theoretical molecular weight is about 12.3 kDa. The software automatically deconvolutes, converting a multiply charged mass spectrum into a single-charged neutral mass spectrum.
The picture above: the theoretical molecular weight is about 4.9 kDa. The software automatically deconvolutes it, converting the multi-charge mass spectrum into a single-charge neutral mass spectrum.
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Adapted for various core scenarios: In the early stages of new drug development, it's great for quickly screening candidate peptides, and in biopharmaceuticals, it can monitor drug degradation or modifications in real time. During method development, it helps quickly evaluate and optimize conditions, and the real-time deconvolution feature lets you confirm sample molecular weight. Overall, it's an ideal choice for sample pre-screening and fast quality control.
The synthesizer produces high-purity and steady output, and the mass spectrometer gives lightning-fast feedback.
R&D cycles are greatly shortened, and trial-and-error costs drop straight down.
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