Simple-to-Complex Peptide Synthesis Instrument—PurePep® Chorus

Modular design, custom-made to meet your needs.

In the fields of academic and industrial research, peptide synthesis technology is continuously pushing the boundaries of efficiency and purity. PurePep ^® As a modular synthesizer, Chorus centers on flexible configuration and intelligent features, providing researchers with an efficient and reliable synthesis experience.

The key advantage of the PurePep Chorus is its configurable parallel synthesis capability. The instrument is initially configured with 2 channels (i.e., 2 reaction vessels), but can be expanded and upgraded to 4 or 6 channels in the future as demand grows. Additionally, independent induction heating and real-time UV monitoring modules can be customized according to specific requirements.

PurePep Chorus Overview

Overview of Advantages

● Configurable parallel synthesis

Modular design allows optional configuration with 2, 4, or 6 channels for parallel or sequential synthesis of multiple peptides.

● High purity

The chemically inert valve block system, PurePep Pathway, achieves low dead volume and zero cross-contamination, thereby enhancing purity and yield. The Single-Shot™ amino acid delivery system further ensures high purity while minimizing the use of costly reagents.

● Real-time UV monitoring

The Intellisynth real-time UV monitoring module can monitor the reaction solution in the mixture, optimize reaction time, and ensure complete deprotection. In a single synthesis, Intellisynth can monitor up to six peptides.

● Controllable induction heating accelerates peptide synthesis.

Six different temperatures can be used simultaneously to accelerate chemical reactions. The target temperature is rapidly reached within 10–20 seconds, enhancing the purity of complex reaction sequences. This enables precise and reproducible synthesis.

● Automatic peptide cleavage, boosting throughput

Self-configured, fully automated peptide cleavage helps increase throughput, enhance safety, and extend unattended operating time.

Intuitive software interface

The graphical PurePep Chorus software is designed to meet the efficiency demands of chemical researchers. Its conveniently accessible, portable tablet allows users to wirelessly set up synthesis procedures, while its intuitive workflow guidance makes the instrument easy to use for both beginners and experienced users alike. Software features include: an enhanced graphical software platform that enables simple and intuitive sequence and method setup; an upgraded database of amino acids, solvents, and reagents that makes operations even easier and faster; and the flexibility to freely choose between standard or custom synthesis programs.

The graphical software platform offers convenient and intuitive sequence and method setup. The flexible choice between standard or user-defined synthesis programs provides versatility.
The SafePep™ function automatically flushes the resin to prevent errors and ensure that no byproducts are synthesized.
UV data is provided in real time during the synthesis process, and all data can be reviewed after synthesis. Single-cycle graphs and summary graphs provide valuable information for troubleshooting and diagnosis.
Email notifications are used to remotely confirm the synthesis status—whether it’s proceeding as scheduled or requires attention.
21 CFR Part 11 is designed to ensure compliance with regulatory requirements such as user management, electronic signatures, and audit trail tracking.

We also provide IQ/OQ validation support and PQ guidelines to ensure that scientists can confidently use PurePep Chorus in a highly regulated cGMP laboratory environment.

PurePep® Chorus, with its modular upgrades and intelligent features, helps laboratories break through efficiency bottlenecks in peptide synthesis and provides a robust toolset to support drug development and basic research.

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