Determination of Moisture Content in Nicosulfuron Technical Grade Substance

Reference standard: GB 29383-2012 Nicosulfuron technical grade substance

[ Scope 】

This standard specifies the requirements for pyrazosulfuron-ethyl technical grade, the test methods, as well as the labeling, packaging, storage, transportation, and acceptance criteria.

This standard applies to the technical grade of nicosulfuron, which consists of nicosulfuron itself and impurities generated during its production.

Note: For other names, structural formulas, and basic physicochemical parameters of nicosulfuron, see Appendix A.

【Requirement】

Appearance: A grayish-white to earthy-yellow solid in granular or powdered form, free from any visible foreign matter and added modifiers.

Technical indicators: The technical grade of nicosulfuron shall also meet the requirements specified in Table 1.

[Experimental Method]

Determination of moisture content: Perform the test according to the "Karl Fischer method" specified in GB/T 1600. The use of a micro moisture analyzer with comparable accuracy is permitted.

GB/T 1600-2001 — Method for Determination of Moisture Content in Pesticides

Appendix A (Informative Appendix)

Other names, structural formulas, and basic physicochemical parameters of nicosulfuron

The other names, structural formula, and basic physicochemical parameters of the active ingredient of this product, nicosulfuron, are as follows:

Generic name: Nicosulfuron

ISO common name: nicosulfuron

CAS Registry Number: 111991-09-4

Chemical name: 2-(4,6-Dimethoxypyrimidin-2-ylcarbamoylsulfamoyl)-N,N-dimethyl nicotinamide

Structural formula:

Empirical formula: C ₁₅ H ₁₈ N ₆ O ₆ S

Relative molecular mass: 410.4

Bioactivity: Herbicide

Melting point: 141°C~144°C

Vapor pressure: 1.6 × 10⁻¹¹ Pa (20°C)

Solubility (25°C, g/kg): Water: 3.59 (pH=5 buffer solution), 12.2 (pH=7 buffer solution), 39.2 (pH=9 buffer solution); Acetone: 18; Ethanol: 4.5; Chloroform, Dimethylformamide: 64; Acetonitrile: 23; Toluene: 0.37; n-Hexane: <0.02; Dichloromethane: 160

Stability: The aqueous solution has a DT50 of approximately 15 days at 25°C (pH 5) and is stable at pH 7 and pH 9.

[Recommended]

Karl Fischer Moisture Analyzer CA-310 Volumetric Method

Instrument features:

1. Higher detection accuracy: Under ideal conditions, it can detect trace amounts of moisture (absolute water content as low as 5 μg) with excellent repeatability.

2. The console can connect to up to 4 detection channels. Multiple channels provide better reference for experimental results and also enhance detection efficiency.

3. Standard Operating Procedure (S.O.P.) Recording: A standard operating procedure for testing a specific sample can be entered into the instrument. Subsequently, the instrument will automatically prompt the operator to perform the sample test according to the standard operating method.

Technical specifications:

Technical Specifications of the CA-310 Volumetric Micro Moisture Analyzer
Measurement method	Karls Fischer volumetric titration Simultaneous 4-channel measurement (optional)
Moisture determination range	0.1 ~ 999.999 mg H2O
Display screen	8.4-inch color LCD touch screen, supports Chinese operation
File storage	Detailed experimental data storage: 9,999 entries Instrument timing start/stop setting options: 99 types
Printer	Optional thermal printer or impact printer.
Moisture vaporization device	Can be used with VA-300, VA-200, VA-210, VA-230, VA-236S, VA-121, and VA-122 gasification units all feature stepwise temperature control functionality.
Bromine detection mode Burette	Volume: 10 ml (optional with 2 ml, 5 ml, or 20 ml burettes) Titration accuracy: 0.1% Reagent filling speed: 0.7 ml/1 sec
External Access I/O	Electronic balance: Automatic weight input 4 USB ports, 1 LAN port Import or export experimental data, backup/restore settings

Keywords:

Borneol content in borneol

Pharmaceutical professionals gather in Shanghai! A sneak peek at the highlights of CPHI & PMEC China 2025 at Shanghai Hanyao.