Sterile Thin-Film Evaporator

The sterile thin-film evaporator is a new type of highly efficient evaporator that uses a “gas knife” formed by the high-speed rotation of an integrated impeller to forcibly create a thin film. It operates under certain vacuum conditions and enables falling-film evaporation. This evaporator boasts a high heat-transfer coefficient, high evaporation intensity, short residence time, and adjustable operating parameters. It is particularly suitable for removing organic solvents and concentrating products such as liposomes, microspheres, peptide intermediates, and other heat-sensitive substances.

Working principle

The material enters the evaporator through the feed inlet at the top and, driven by the high-speed rotating impellers, forms an “air knife” that is continuously distributed along the inner wall of the evaporation cylinder. The steam generated from the evaporation cylinder rises to the vacuum pipe, where it is condensed by the condenser. The condensed solvent then flows into a collection tank, while the concentrated product after evaporation flows out from the bottom of the evaporator.

Suitable for the removal of organic solvents and concentration of products in liposomes, microspheres, peptide intermediates, and other heat-sensitive products.

Product Features

The evaporation and concentration effect is excellent, enabling solvent residues as low as 10 PPM.
The evaporation and concentration process operates at a low temperature, enabling product evaporation and concentration at 10–15°C.
Heated with hot water, the thermal effect is gentle, minimizing the risk of localized overheating that could affect the product.
Adopts a hygienic design compliant with ASME BPE, featuring no dead corners and enabling CIP and SIP processes to meet sterile requirements.
Integrated blade with high precision and excellent coaxiality, ensuring uniform film formation.
Strengthen the design of the heat-exchange jacket for high heat-transfer efficiency;
Optional explosion-proof design available to meet the requirements for use in hazardous areas.
Optional temperature control system (TCU), vacuum system, and CIP station available as accessories for Jiewei.

Product Specifications

Model	Evaporation area m ²	Applicable viscosity CP	Processing rate ml/min	Working speed rpn	Work stress par
JW-TFERO.03-0.75	0.03	0~3000	≤50	≤2000	-1~3 bar
JW-TFERO.1-4.0	0.10	0~3000	≤250	≤1800	-1~3 bar
JW-TFERO.3-7.5	0.30	0~3000	≤500	≤1200	-1~3 bar
JW-TFERO1.0-11.0	1.00	0~3000	≤1800	≤500	-1~3 bar
JW-TFES0.03-0.75	0.03	3,000–50,000	≤50	≤200	-1~3 bar
JW-TFES0.1-2.0	0.10	3,000–5,000	≤250	≤200	-1~3 bar
JW-TFES0.3-4.0	0.30	3,000–50,000	≤500	≤200	-1~3 bar

Customizable according to customer needs.

Keywords:

Analysis of the Nonionic Contrast Agent Iohexol by UHPLC-CMS Method

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