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2026
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A full-chain peptide solution to tackle common industry pain points
The 5th Peptide Industry Innovation and Development Forum (Suzhou) has successfully concluded. At the Shanghai Hanyao booth, we covered the entire process from peptide research and development, synthesis, purification, post-processing, production, to quality control, and received real questions straight from industry professionals. We've compiled the most frequently asked questions into a Q&A format, offering practical industrial solutions with a multi-product, full-chain coverage approach.
问
How can we quickly and stably synthesize long-chain peptides and smoothly scale up the process?
When synthesizing long-chain peptides (like GLP-1 analogs, complex cyclic peptides, or PDCs), the industry often faces pain points like low coupling efficiency, many missing sequences, poor crude purity, decreased yields after scaling up, inconsistent batches, and incomplete compliance data.
We use the full range of peptide synthesizers (click to see more details) with a compliance-controlled platform to solve problems together:
The full range of peptide synthesizers (PurePep® Chorus, Symphony® X, PurePep® Sonata®) covers everything from small-scale R&D, process optimization, to pilot-scale production. With high-precision fluid control, optimized stirring, and mass transfer modes, they greatly improve the synthesis stability and first-time success rates for long-chain, difficult cyclized, and multi-modified peptides.
Key process parameters can be transferred and scaled 1:1 accurately, avoiding common problems like purity drops and yield decreases when moving from lab to pilot scale.
The entire series supports 21 CFR Part 11 compliance, with built-in electronic records, audit trails, and access control. Data is complete and traceable, directly meeting CMC filing and GMP site inspection requirements.
For material transfer before and after synthesis and between process steps, the ABC Transfer® ultra-clean sterile transfer solution allows fully enclosed transport, preventing exposure and cross-contamination, ensuring the safety of high-activity peptides throughout the entire process.
问
How can we reduce solvent use and improve system stability in large-scale purification?
Large-scale peptide purification commonly faces pain points like high organic solvent usage, high operating costs, environmental pressure, system leaks and blockages, and frequent downtime with high-salt buffers, all of which directly affect continuous production and cost control.
We use a combined solution of the SFC supercritical fluid chromatography system (click for more details) and HPLC accessories and consumables (click for more details) to achieve both greener efficiency and stable operation:
The Sepiatec SFC system uses CO₂ as the main mobile phase, significantly reducing organic solvent consumption, speeding up separation, and providing better peak shapes. It's especially suitable for high-value products like peptides, PDCs, and chiral peptides, offering low carbon, safety, and cost advantages.
The system supports stacked injection, automated method development, and atmospheric fraction collection, handling higher throughput and simplifying downstream processing, making it easy to scale up from analysis to preparation.
The supporting HPLC accessories and consumables (high-pressure and corrosion-resistant tubing connectors, online filters, check valves, membranes, deuterium lamps, etc.) can withstand high salt, extreme pH, and strong organic solvent environments for the long term, reducing system backpressure, preventing leaks and clogging, greatly reducing unplanned downtime, and improving both continuous run time and data reliability of the purification system.
During the transport and transfer of intermediates after purification, a sterile transfer system is used throughout, ensuring safe, closed, and smoother workflow connections.
问
How can we prevent thermo-sensitive peptides from degrading during concentration and make sure the formulation stays intact?
Thermosensitive materials like peptides, proteins, liposomes, and microspheres can easily suffer from heat-induced denaturation, reduced activity, carrier breakage, lower encapsulation rates, and excessive solvent residues during concentration and solvent removal. At the same time, they need to meet sterility and clean sterilization requirements.
The sterile film evaporator (click to see more details) is a dedicated solution for this kind of scenario, with outstanding advantages:
It uses vacuum low-temperature (10–15℃) film evaporation. The material stays in the equipment for a very short time, is gently heated, maximally protecting biological activity and preventing degradation, polymerization, and denaturation.
Solvent residues can be as low as 10 PPM, with uniform film formation and high heat transfer efficiency. Concentration and solvent removal are completed in one step, making it especially suitable for mild post-processing of liposomes, nano-formulations, and peptide intermediates, ensuring the carrier's structure remains intact and the encapsulation rate is high.
It features an ASME BPE sanitary design with no dead corners, supporting CIP/SIP online cleaning and sterilization. It can be equipped with TCU temperature control, vacuum systems, and explosion-proof configurations, fully meeting sterile workshop and compliance production requirements.
From feeding and concentrating to discharge transfer, the entire process can be seamlessly integrated and sealed through the ABC sterile transfer system, achieving a smooth and sterile workflow.
问
In the full production process of high-activity peptides, how can safe and sterile transportation be achieved?
Highly active, highly sensitizing, and highly toxic peptides pose exposure risks and cross-contamination hazards at every stage, including synthesis, purification, concentration, formulation, filling, and QC sampling. Traditional pass-through windows are complicated to use, expensive to validate, and can't meet high-level sterile requirements.
ABC Transfer® Ultra-Clean Sterile Transfer Solution （Click to see more details）Can be used throughout the entire peptide production chain, becoming the standard for transporting high-activity materials:
Uses a glove-free quick docking, fully enclosed transfer mode, ensuring the material is never exposed, touched, or contaminated during the whole process. This prevents cross-contamination and personnel exposure from the start and meets high-level sterile standards like GMP Annex 1.
The interface works with single-use transfer bags or sterile containers, connecting quickly and easily, greatly improving workflow efficiency between steps, while reducing sterile operation time and human interference.
Designed for single-use or sterilization, which cuts down on CIP/SIP validation work. Compatible with isolators, RABS, sterile filling lines, and high-activity workshops, truly enabling safe, compliant, and efficient full-process handling.
问
How can recombinant peptide biosynthesis improve expression levels and process stability?
Recombinant peptides and biosynthetic peptides often face bottlenecks like low expression levels, big process fluctuations, inaccurate control of pH/oxygen/temperature, difficulty scaling up, and long production cycles, which affect industrial progress and costs.
GETINGE（Applikon）Bioreactor and Control System（Click to see more details）Providing one-stop bioprocess support:
Achieve high-precision closed-loop control of multiple parameters like pH, dissolved oxygen, temperature, stirring speed, and feeding, making the environment more stable and significantly boosting peptide expression and batch consistency.
The platform covers small-scale to pilot-scale, with methods that can be seamlessly scaled up. Combined with perfusion separation, online monitoring, and automation modules, it reduces manual intervention and improves process robustness.
User-friendly software, traceable data, and support for compliance documentation make it suitable for the entire workflow, from cell line construction and process development to large-scale production.
All transfers of cell materials, media, intermediates, etc., are ensured by the ABC sterile transfer system, reducing contamination risk and enhancing bioprocess safety.
问
How can peptide quality control testing be done quickly, accurately, and still meet compliance for release?
Testing key indicators like moisture, potential, and titration values for peptide raw materials, intermediates, and finished products often faces issues like slow speed, poor accuracy, high human error, unreliable data, and delays in release cycles.
We use a combination of the Karl Fischer Moisture Analyzer and the Automatic Potentiometric Titrator (click to see more details) to achieve efficient and accurate quality control:
The Karl Fischer CA310 features a highly sensitive sensor and automated process, offering fast detection, stable results, and precise measurement of trace moisture, meeting the high QC standards required for APIs and formulations.
The Automatic Potentiometric Titrator GT310 provides fully automatic titration, calculation, and recording, reducing human error, improving data repeatability and reliability, and supporting compliant data retention and audit tracking.
This complete solution greatly shortens testing cycles, boosts QC efficiency, and provides stable, accurate, and efficient technical support for raw material inspection, process control, and finished product release.
Conclusion
The core demand of the peptide industry has never been just upgrading a single piece of equipment, but a fully integrated solution that is stable, compliant, efficient, and cost-effective across the whole process.
Shanghai Hanyao offers a complete product matrix from peptide synthesis — green purification — gentle post-processing — full-process sterile transfer — bioprocessing — to quality control testing. This truly enables multi-equipment collaboration, cross-stage integration, and full-scenario coverage, providing reliable support for peptide innovative drug development and industrialization.
In the future, Hanyao will continue to focus deeply on the peptide field and work hand in hand with industry partners to explore peptide possibilities and create a win-win future!
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