How to Choose a Polypeptide Synthesizer That Meets Your Needs

How to Choose a Polypeptide Synthesizer That Meets Your Needs?

In the development of therapeutic drugs, the ability to synthesize high-purity peptides on a large scale and in parallel across multiple sequences is crucial for transitioning from basic research to production applications.

The peptide synthesizer offered by GPT can meet diverse peptide synthesis needs in terms of purity, yield, and scale (0.005–200 mmol). Whether you’re preparing combinatorial chemical libraries, small organic molecules, peptides (Fmoc or t-Boc), peptidomimetics, or oligonucleotides, there’s always a product that fits your requirements.

All instruments continue to uphold our core principles—high purity, high efficiency, and high performance.

The software complies with. 21 CFR Part 11 Requirements

Innovative Technologies in Gyros Protein Technologies Instruments

Intellisynth ^® UV Monitoring: Visualizing the Mixed Reaction Process

The Symphony X and PurePep Chorus synthesizers can be optionally equipped with a proprietary Intellisynth real-time UV monitoring module. On the Symphony X, the UV module can be installed on the first of 24 reaction vessels. On the PurePep Chorus, the UV monitoring module can be fitted to any number of reaction vessels as needed, enabling automatic optimization of deprotection reactions.

During synthesis, real-time UV data can be viewed, and upon completion, comprehensive data can be obtained. The single-cycle plot displays the reaction process for each individual cycle, while the summary plot highlights the differences in time and number of repetitions across different cycles, providing valuable troubleshooting information for synthesizing challenging sequences.

Unlike waste-liquid monitoring used by other instruments, Intellisynth monitors the reaction solution during mixing, allowing precise control of the deprotection reaction time—rather than merely relying on the number of reaction cycles. This enables you to identify optimal conditions right from the first synthesis, eliminating unnecessary waste of reagents.

Induction heating

Speed up the reaction, improve purity.

Induction heating is a rapid heating technology used for reaction vessels on the PurePep Chorus synthesizer. When synthesizing challenging sequences, this technology accelerates chemical reactions and enhances product purity. It can be configured for any number of reaction vessels as needed. The heating conditions for each reaction vessel can be set independently, making it easy to scan temperatures for process optimization or to synthesize sequences in parallel using different methods. During synthesis, real-time temperature data can be monitored, and upon completion, all data can be reviewed retrospectively.

Real-time traffic monitoring

Precise liquid delivery , Low calibration requirements

Real-time flow monitoring technology is a proprietary feature of PurePep Sonata+. It continuously monitors flow rate to ensure the accuracy and precision of liquid delivery. This technology is based on sonar principles and measures flow rate by transmitting sonar signals in both directions. For liquids with different viscosities, only one calibration is required, reducing the need for frequent user calibrations and saving time. Even when flow rates change, this technology maintains high precision, with measurement errors for various liquids below 5%.

PUREPEP internal flow path

Guarantee peptide purity

All synthesizers are equipped with the proprietary PurePep Pathway (valve module and microfluidic system). This innovative design features zero dead volume, no cross-contamination, and maintenance-free operation for several years. With the PurePep flow path, you can consistently obtain high-purity peptides every time.

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