From the glove box straight to the mass spectrometer—iASAP effortlessly tackles the challenge of detecting air-sensitive compounds.

iASAP—Born for air-sensitive compounds!

In the field of chemical analysis, the detection of air-sensitive compounds has long posed numerous challenges. Traditional methods often require complex sample pretreatment and cumbersome operational procedures, which are not only time-consuming and labor-intensive but also prone to oxidation or degradation of the samples, thereby compromising the accuracy of analytical results.

Traditional pain points

1. Oxidation/Hydrolysis Risk: Air-sensitive samples—such as metal complexes and compounds sensitive to hydrolysis—once exposed to air will rapidly react with oxygen or moisture, leading to structural degradation, loss of activity, and even complete failure.

2. Data distortion: If the sample degrades during transfer, the mass spectrometry analysis results will fail to reflect the true composition, thereby undermining the credibility of scientific conclusions or quality control measures.

3. Complicated operation: Traditional methods require multiple transfers and complex pre-processing steps (such as cryoprotection and sealing containers), which are time-consuming, labor-intensive, and prone to high failure rates.

✅ Pain Point Terminator: iASAP

The emergence of iASAP (Inert Atmosphere Solid Analysis Probe) technology has brought a brand-new solution to this challenging problem. Without the need for sample pretreatment or chromatographic separation, iASAP technology allows samples to be transferred directly from an inert environment—such as a glove box or Schlenk line—to the mass spectrometer for rapid analysis. The entire process is carried out under inert gas protection, effectively preventing the sample from being exposed to air and thus avoiding degradation, thereby ensuring the accuracy and reliability of the analytical results. Whether it’s reaction monitoring, compound identification, food safety testing, or natural product analysis, iASAP can handle these tasks with ease, providing chemists with a fast, simple, and highly efficient analytical tool.

iASAP Ion Source Core Advantages

✅ Inert gas full-process protection Directly transfer samples from the glove box/Schlenk line, completely isolating them from air interference and maximizing sample stability!

✅ Zero-sample preparation No chromatographic separation required, Within 1 minute Get data quickly!

✅ Sealed Three-Way Valve Design Inert gas purging + sealed transfer—ensuring sample stability!

Why choose iASAP?

✅ APCI Ion Source Upgrade: A Powerful Tool for Small-Molecule Analysis—Combining High Sensitivity and Accuracy!

✅ Suitable for highly sensitive samples: Successfully analyzed [Ni(cod)₂⁺], which is hydrolysis-sensitive. P–Si–P ferrocene ring ([M+H]⁺ peak m/z 459.0, the isotopic distribution perfectly matches the theoretical value)!

Sample 1 Information: [Ni(cod)₂]⁺[Al(OC(CF₃)₃)₄]⁻ is an organometallic compound containing nickel and aluminum. The cationic part is [Ni(cod)₂]⁺, where Ni stands for nickel and cod represents the cycloocta-1,5-diene ligand, with the chemical formula C₈H₁₂. The molar mass of [Ni(cod)₂]⁺ is 274 g/mol, while the molar mass of [Ni(cod)]⁺ is 166 g/mol.

Sample 2 Information: P–Si–P ferrocenophane is an organometallic compound containing iron, phosphorus, and silicon, characterized by a unique structure and properties. It consists of two phosphine groups connected via a silicon atom and forms a cyclic structure with an iron atom, exhibiting excellent chemical stability and distinctive electronic properties.

✅ Synthesis verification case: Complex compounds such as Ag(As₂S₃)₂[Al(OClCF₃)₃]₄—data are accurate and reliable!

Sample 3 Information: Ag(As4S3)2[Al(OC(CF3)3)4] is a complex organometallic compound containing silver, arsenic, sulfur, and aluminum, characterized by a unique structure and properties. Cationic part Ag(As4S3)2, where Ag stands for silver and As4S3 is an arsenic sulfide ligand. This portion forms a complex cationic structure. Anion part [Al(OC(CF3)3)4]–, where Al represents aluminum and OC(CF3)3 is the trifluoromethyl carbonate ligand, also known as the triflate ligand. This moiety provides the overall compound with a negative charge.

How do I use iASAP?

The core of iASAP technology lies in its unique sampling device. This device consists of an extended ASAP probe, which is protected by an external sheath and equipped with a three-way valve.

✅ Sample Collection: During use, first transfer the sample to the iASAP probe under the protection of an inert gas, from either a glove box or a Schlenk line.

✅ Sample Transfer: Use a three-way valve to flush the system, ensuring the entire apparatus is filled with an inert gas. Finally, seal the apparatus and safely transfer the sample to the mass spectrometer for analysis.

Application scenarios

✅ Real-time reaction monitoring

During a chemical reaction, timely understanding of the reaction progress and the formation of products is crucial for optimizing reaction conditions. The iASAP technology enables rapid and direct analysis of reaction mixtures, allowing real-time monitoring of dynamic changes in the reaction and providing chemists with invaluable information.

✅ Natural product identification

For certain naturally occurring compounds that are prone to oxidation—such as specific alkaloids or flavonoid compounds—the iASAP technology, under the protection of an inert gas, can effectively prevent sample oxidation, thereby ensuring the accuracy and reliability of analytical results.

✅ Analysis of Metal Complexes

In the synthesis and identification of metal complexes, iASAP technology has demonstrated unique advantages. For example, when analyzing an air-sensitive metal complex, iASAP technology successfully provided accurate mass spectrometry data in a short time, enabling researchers to rapidly determine the compound’s structure and composition.

Easy to operate

✅ With expression® CMS Mass Spectrometer Seamless integration and a compact design save space! Easy to clean, with a smooth transition between experimental steps—saving researchers 50% of their lab time!

iASAP makes complex analytics simple!

The iASAP technology has revolutionized the field of chemical analysis with its unique features: no need for sample pretreatment, no requirement for chromatographic separation, rapid analysis, and a wide range of applicability. Not only does it simplify the analytical process and save time and costs, but it also provides a reliable method for detecting air-sensitive compounds, thereby propelling chemical research to new heights.

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